Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29.
نویسندگان
چکیده
After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).
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عنوان ژورنال:
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
دوره 17 6-7 شماره
صفحات -
تاریخ انتشار 2007